Studies about vitamin D and multiple sclerosis:

Month of Birth and the Incidence of Multiple Sclerosis in Southern Iran (2014)

Conclusion: In Southern Iran, people with multiple sclerosis are disproportionately born around the beginning of Spring (when population vitamin D levels are lowest) and the risk for multiple sclerosis is lowest for people born at the beginning of Fall (when population vitamin D levels are highest).


Suppression of Experimental Autoimmune Encephalomyelitis by 300-315nm Ultraviolet Light (2013)

Conclusion: In this study mice with autoimmune encephalomyelitis, an animal model of multiple sclerosis, were exposed to various intensities of ultraviolet A radiation and ultraviolet B radiation to see what effects the light had on the disease. Ultraviolet A radiation had no effect at all on suppressing encephalomyelitis in mice, but Ultraviolet B exposure DID. Ultraviolet B exposure suppressed and delayed the onset of encephalomyelitis. Another interesting thing is that none of the light exposures raised vitamin D levels in the mice, leading researchers to conclude that there is some other element at play with the Ultraviolet B radiation BESIDES vitamin D production that improves immunoregulation. This could also, however, be due to people and animals with multiple sclerosis having impaired vitamin D endocrine systems (which is documented), the mice maybe not receiving enough UV exposure to synthesize vitamin D, or that the mice, as the authors noted, ALREADY had sufficient vitamin D levels before exposure.


The Month of Birth Effect in Multiple Sclerosis: Systematic Review, Meta-Analysis and Effect of Latitude (2013)

Conclusion: People with multiple sclerosis are disproportionately born around the beginning of Spring (when population vitamin D levels are lowest) and the risk for multiple sclerosis is lowest for people born at the beginning of Fall (when population vitamin D levels are highest).


Vitamin D Status Predicts New Brain MRI Activity in Multiple Sclerosis (2012)

Conclusion: In a study of 469 multiple sclerosis patients, those with higher vitamin D levels had lower brain lesion activity, lower disability, and lower relapse rates.


The Epidemiology of Multiple Sclerosis in Scotland: Inferences from Hospital Admissions (2011)

Conclusion: There is an increased rate of multiple sclerosis cases in Northern Scotland compared to Southern Scotland.


Season of Birth and Multiple Sclerosis in Sweden (2010)

Conclusion: In Sweden, people with multiple sclerosis are born more in June and less in December/January, adding support to the hypothesis that month of birth affects multiple sclerosis risk.


Higher Levels of 25-Hydroxyvitamin D are Associated with a Lower Incidence of Multiple Sclerosis Only in Women (2008)

Conclusion: “Our data suggest that higher circulating levels of 25(OH)D [Vitamin D] are associated with a lower incidence of MS and MS-related disability in women.”


Safety of Vitamin D3 in Adults with Multiple Sclerosis (2007)

Conclusion: For 28 weeks, 12 multiple sclerosis patients were given weekly doses of vitamin D ranging from 28,000 IU to 280,000 IU. Although their vitamin D blood levels went far beyond what is currently considered safe, they experienced no negative side effects, and multiple sclerosis brain lesion activity decreased.


Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis (2006)

Conclusion: People with higher vitamin D levels have fewer incidences of multiple sclerosis compared to people with lower vitamin D levels.


Timing of Birth and Risk of Multiple Sclerosis: Population Based Study (2005)

Conclusion: People with multiple sclerosis are more commonly born after winter, when population vitamin D levels are typically at their lowest.


Vitamin D Intake and Incidence of Multiple Sclerosis (2004)

Conclusion: Women who take vitamin D supplements have been found to have a lower risk of developing multiple sclerosis compared to women who do not take vitamin D supplements.


Vitamin D and Seasonal Fluctuations of Gadolinium‐Enhancing Magnetic Resonance Imaging Lesions in Multiple Sclerosis (2000)

Conclusion: Multiple sclerosis patients with lower vitamin D levels suffer more brain lesion activity. Multiple sclerosis patients with higher vitamin d levels suffer fewer brain lesions.


Geographic Variation of MS Incidence in Two Prospective Studies of US Women (1999)

Conclusion: There are more incidences of multiple sclerosis in the northern regions of the United States than the southern regions, which are closer to the equator and enjoy more vitamin D-creating UVB solar radiation.


1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a  Model of Multiple Sclerosis (1996)

Conclusion: Administration of vitamin D was shown to be effective for completely preventing and stopping the progression of a multiple sclerosis-like autoimmune disease artificially induced in mice. Cessation of vitamin D administration resulted in a resumption of the disease’s progression.


High Prevalence of Vitamin D Deficiency and Reduced Bone Mass in Multiple Sclerosis (1994)

Conclusion: 80 women with multiple sclerosis were analyzed. The group had a low average vitamin D level with 23% being very deficient. Those with more severe multiple sclerosis had lower bone density, which is a well-documented symptom of low vitamin D levels. More recently vitamin D deficiency has been strongly associated with multiple sclerosis.



Multiple Sclerosis and (lots of) Vitamin D: My Eight-Year Treatment with The Coimbra Protocol for Autoimmune Diseases by Ana Claudia Domene



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