Studies about vitamin D and multiple sclerosis:

Month of Birth and the Incidence of Multiple Sclerosis in Southern Iran (2014)

Conclusion: In Southern Iran, people with multiple sclerosis are disproportionately born around the beginning of Spring (when population vitamin D levels are lowest) and the risk for multiple sclerosis is lowest for people born at the beginning of Fall (when population vitamin D levels are highest).

 

Suppression of Experimental Autoimmune Encephalomyelitis by 300-315nm Ultraviolet Light (2013)

Conclusion: In this study mice with autoimmune encephalomyelitis, an animal model of multiple sclerosis, were exposed to various intensities of ultraviolet A radiation and ultraviolet B radiation to see what effects the light had on the disease. Ultraviolet A radiation had no effect at all on suppressing encephalomyelitis in mice, but Ultraviolet B exposure DID. Ultraviolet B exposure suppressed and delayed the onset of encephalomyelitis. Another interesting thing is that none of the light exposures raised vitamin D levels in the mice, leading researchers to conclude that there is some other element at play with the Ultraviolet B radiation BESIDES vitamin D production that improves immunoregulation. This could also, however, be due to people and animals with multiple sclerosis having impaired vitamin D endocrine systems (which is documented), the mice maybe not receiving enough UV exposure to synthesize vitamin D, or that the mice, as the authors noted, ALREADY had sufficient vitamin D levels before exposure.

 

The Month of Birth Effect in Multiple Sclerosis: Systematic Review, Meta-Analysis and Effect of Latitude (2013)

Conclusion: People with multiple sclerosis are disproportionately born around the beginning of Spring (when population vitamin D levels are lowest) and the risk for multiple sclerosis is lowest for people born at the beginning of Fall (when population vitamin D levels are highest).

 

Vitamin D Status Predicts New Brain MRI Activity in Multiple Sclerosis (2012)

Conclusion: In a study of 469 multiple sclerosis patients, those with higher vitamin D levels had lower brain lesion activity, lower disability, and lower relapse rates.

 

Sun Exposure and Vitamin D are Independent Risk Factors for CNS Demyelination. (2011)

Conclusion: Vitamin D levels and sun exposure-related skin damage were measure in 216 adults experiencing demyelination of their central nervous systems. These results were compared with 395 healthy, matched controls and the study found that the subjects who reported higher levels of past and recent sun exposure had a reduced risk of CNS demyelination, those with more skin damage resulting from sun exposure had a reduced risk of CNS demyelination, and those with higher vitamin D levels had a reduced risk of CNS demyelination. Sun lovers suffer less multiple sclerosis.

 

The Epidemiology of Multiple Sclerosis in Scotland: Inferences from Hospital Admissions (2011)

Conclusion: There is an increased rate of multiple sclerosis cases in Northern Scotland compared to Southern Scotland.

 

Season of Birth and Multiple Sclerosis in Sweden (2010)

Conclusion: In Sweden, people with multiple sclerosis are born more in June and less in December/January, adding support to the hypothesis that month of birth affects multiple sclerosis risk.

 

UV Radiation Suppresses Experimental Autoimmune Encephalomyelitis Independent of Vitamin D Production (2010)

Conclusion: Long-term, frequent UVB exposure has a suppressive effect against Experimental Autoimmune Encephalomyelitis, a murine form of multiple sclerosis.

 

Higher Levels of 25-Hydroxyvitamin D are Associated with a Lower Incidence of Multiple Sclerosis Only in Women (2008)

Conclusion: “Our data suggest that higher circulating levels of 25(OH)D [Vitamin D] are associated with a lower incidence of MS and MS-related disability in women.”

 

Safety of Vitamin D3 in Adults with Multiple Sclerosis (2007)

Conclusion: For 28 weeks, 12 multiple sclerosis patients were given weekly doses of vitamin D ranging from 28,000 IU to 280,000 IU. Although their vitamin D blood levels went far beyond what is currently considered safe, they experienced no negative side effects, and multiple sclerosis brain lesion activity decreased.

 

Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis (2006)

Conclusion: People with higher vitamin D levels have fewer incidences of multiple sclerosis compared to people with lower vitamin D levels.

 

Timing of Birth and Risk of Multiple Sclerosis: Population Based Study (2005)

Conclusion: People with multiple sclerosis are more commonly born after winter, when population vitamin D levels are typically at their lowest.

 

Vitamin D Intake and Incidence of Multiple Sclerosis (2004)

Conclusion: Women who take vitamin D supplements have been found to have a lower risk of developing multiple sclerosis compared to women who do not take vitamin D supplements.

 

Cytokine Profile in Patients with Multiple Sclerosis Following Vitamin D Supplementation (2003)

Conclusion: 39 multiple sclerosis patients with low vitamin D levels were enrolled into a randomized, double-blind, placebo-controlled trial. 17 of them took 1000 IU of vitamin D daily for 6 months and the other 22 took no vitamin D. Serum TGF-β1 (transforming growth beta factor 1), a protein that has been found to play a role in reducing multiple sclerosis symptoms, were then measured after the six months. Those treated with vitamin D experienced a significant increase in their TGF-β1 level whereas placebo treatment had no effect on TGF-β1 levels. It’s important to note that 1000 IU is an extremely inadequate dose of vitamin D for adults and that while this dose did increase serum vitamin D levels, it failed to increase vitamin D levels into the sufficiency or optimal range. What effect would a stronger dose of vitamin D have on TGF-β1 levels?

 

Vitamin D and Seasonal Fluctuations of Gadolinium‐Enhancing Magnetic Resonance Imaging Lesions in Multiple Sclerosis (2000)

Conclusion: Multiple sclerosis patients with lower vitamin D levels suffer more brain lesion activity. Multiple sclerosis patients with higher vitamin d levels suffer fewer brain lesions.

 

Geographic Variation of MS Incidence in Two Prospective Studies of US Women (1999)

Conclusion: There are more incidences of multiple sclerosis in the northern regions of the United States than the southern regions, which are closer to the equator and enjoy more vitamin D-creating UVB solar radiation.

 

1,25-Dihydroxyvitamin D3 Reversibly Blocks the Progression of Relapsing Encephalomyelitis, a  Model of Multiple Sclerosis (1996)

Conclusion: Administration of vitamin D was shown to be effective for completely preventing and stopping the progression of a multiple sclerosis-like autoimmune disease artificially induced in mice. Cessation of vitamin D administration resulted in a resumption of the disease’s progression.

 

High Prevalence of Vitamin D Deficiency and Reduced Bone Mass in Multiple Sclerosis (1994)

Conclusion: 80 women with multiple sclerosis were analyzed. The group had a low average vitamin D level with 23% being very deficient. Those with more severe multiple sclerosis had lower bone density, which is a well-documented symptom of low vitamin D levels. More recently vitamin D deficiency has been strongly associated with multiple sclerosis.

 

Books

Multiple Sclerosis and (lots of) Vitamin D: My Eight-Year Treatment with The Coimbra Protocol for Autoimmune Diseases by Ana Claudia Domene

 

 

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