Search by category for studies on vitamin D and old age degenerative disease:
Low Serum Vitamin D Concentrations in Alzheimer’s Disease: A Systematic Review and Meta-Analysis (2013)
Conclusion: This study found that Alzheimer’s disease patients studied had lower vitamin D levels than matched healthy controls, concluding that “this reinforces the conceptualization of vitamin D as a ‘neurosteroid hormone’ and as a potential biomarker of AD.”
Effectiveness of the Combination of Memantine Plus Vitamin D on Cognition in Patients with Alzheimer Disease: A Pre-Post Pilot Study (2012)
Conclusion: Alzheimer’s patients in this study receiving vitamin D supplements experienced significantly improved cognitive health compared to those not receiving vitamin D.
Conclusion: This study followed and the tested the vitamin D levels of 13,331 adults for a period of 6-12 years. In a controlled analysis, those in the lowest vitamin D level quartile were found to have a 26% increased rate of all-cause mortality compared to those in the highest vitamin D level quartile. In the unadjusted analysis, the mortality risk was 78% higher.
Photoprotection by 1,25 Dihydroxyvitamin D3 Is Associated with an Increase in p53 and a Decrease in Nitric Oxide Products (2007)
Conclusion: Vitamin D and UV exposure “induce high levels” of the anti-cancer, tumor-suppressing, DNA-repairing p53 protein.
Low Serum Concentrations of 25-Hydroxyvitamin D in Older Persons and the Risk of Nursing Home Admission (2006)
Conclusion: A 6-year study of 1,260 independent elderly people in Amsterdam found that those with lower vitamin D levels were more likely to end up in nursing homes.
Vitamin D Deficiency Is Associated With Low Mood and Worse Cognitive Performance in Older Adults (2006)
Conclusion: 40 elderly people with alzheimer’s disease and 40 non-demented elderly people who were participating in studies at the Alzheimer’s Disease Research Center were evaluated. Their vitamin D levels, physical performance, and cognitive/mental health were measured with a variety of mental health tests. The vitamin D results were not good. The average level of the entire group was only 18.5 ng/ml and 58% had “abnormally low” vitamin D levels. Those who were vitamin D-deficient were found to have a higher prevalence of mood disorders and scored worse on the Short Blessed Test (SBT) and the Clinical Dementia Rating test (CRD).
Conclusion: This study of 1,619 elderly women living in nursing home facilities found that 22% of them women receiving low-level care had a severe vitamin D deficiency of <10 ng/ml and a shocking 45% of the women in high-level care were deficient below 10 ng/ml. The study also found that with each doubling of vitamin D levels, the risk of falling among the women dropped by 20%.
Conclusion: 269 elderly people living in retirement homes were evaluated for their vitamin D levels their physical performance in isometric strength tests and a 6-minute walking test. The rate of vitamin D-deficiency was significantly higher in the women than in the men and vitamin D status was significantly correlated with physical performance in the female subjects. Among the women, those with the lower vitamin D levels demonstrated lower arm and leg muscle strength and reported more disability than those with higher vitamin D levels. The study also found that vitamin D levels were significantly lower in the winter for everyone.
Conclusion: Over a 5-year period 341 elderly people were given annual vitamin D megadose injections (150,000 IU – 300,000 IU vitamin D2) and their fracture rate during that period was compared to a group of 458 matched controls not receiving vitamin D. The vitamin D group experienced 6% fewer fractures than the control group. This is actually impressive considering that an annual dose of 150,000-300,000 IU amounts to only about 400 IU – 800 IU per day, which leading vitamin D experts agree is completely inadequate for adults, possibly even inadequate for infants, and even more inadequate for seniors. Vitamin D2 has also been found to be only about 25% as effective for raising human vitamin D levels than vitamin D3 and the half life of vitamin D is only a few months max, making an annual megadose the least reliable way of maintaining year-round adequate vitamin D status. Despite the vitamin D group receiving essentially meaninglessly insufficient vitamin D treatment, they experienced measurably superior health outcomes and no signs of vitamin D toxicity were observed following the 300,000 IU megadoses.
Conclusion: For 18 months 1634 elderly women received a daily calcium supplement and 800 IU of vitamin D3 and their fracture rates, bone density, and parathyroid hormone levels were compared to another 1636 elderly women receiving placebos. At the end of the study the vitamin D group had suffered 43% fewer hip fractures, 32% fewer nonvertebral fractures, a vitamin D blood level increase of 162%, and parathyroid hormone level reduction of 44% compared to the placebo group. The vitamin D group also enjoyed a 2.7% increase in their bone mineral density, whereas the placebo group suffered a 4.6% decrease in their bone mineral density.
Myopathy in Bone Loss of Ageing: Improvement by Treatment With 1 Alpha-Hydroxycholecalciferol and Calcium. (1979)
Conclusion: Vitamin D supplementation improves old age-related myopathy.